Product

Get answers faster with Delve Detect

Simplify your meningitis/encephalitis workup. Identify infectious bacteria, viruses, fungi, and parasites using a single test.

Our Product

Traditional, targeted tests offer a frustrating guessing game with too many tests and too few answers. Metagenomic sequencing (mNGS) ends the cycle – in just 48 hours. Our free, easy-to-use kit enables overnight shipping of CSF samples at room temperature.

Delve Detect CSF

Sample type
Cerebrospinal fluid
Technology
Delve Decide mNGS
Pathogens
RNA and DNA
Turn around time
< 48 hours

Real world evidence highlights clinical impact of mNGS (CSF)

From the largest cohort analyzed-to-date involving more than 4,800 patients, mNGS (CSF) provides more comprehensive microbial analysis than other infectious disease tests.1

437

pathogens identified

17.8%

positivity rate*

22%

greater diagnostic yield

*14.4% positivity when samples with multiple taxa are removed.

Prospective, multicenter clinical trial demonstrates the clinical actionability of mNGS2

Year-long, multi-center, prospective enrollment with over 200 patients from hospitals across the United States demonstrates actionability of mNGS results.2

54%

of clinical diagnoses made by mNGS alone resulted in treatment change

22.4%

of infections missed by standard microbiological testing

55%

of diagnoses were made using mNGS – alone or in conjunction with other testing

Learn more about mNGS
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Clinical Microbial Sequencing Board (CMSB)

Delve Bio’s Expert Clinical Consultation

Connect with Delve’s clinical and medical experts through our Clinical Microbial Sequencing Board (CMSB):

  • HIPAA-compliant clinical consultation available before, during, and after testing
  • Included with every Delve order at no additional cost
  • Expert guidance on the utility and appropriate use of Delve Detect
  • Comprehensive review of clinical context, including patient presentation, symptoms, timing, severity, and current treatments
  • Clear support for reading and interpreting your results reports with confidence

Request a CMSB any time:

  • Before an order: assess suitability of mNGS for a patient
  • During and after results delivered: review clinical context and how to interpret mNGS results
Talk to our medical team
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A diagnosis makes all the difference3

A 14-year-old with severe combined immunodeficiency developed an infection that progressed from a headache to seizures requiring a medically induced coma.

After multiple hospitalizations, more than 40 diagnostic tests and a brain biopsy, there was still no clear answer on what was wrong.

Finally, a mNGS CSF test was ordered.

Within hours, mNGS identified a bacterial pathogen (Leptospira), despite previous negative microbiological testing. 48 hours after treatment started, the patient was conscious. He was home and back to normal within a month – thanks to the accurate diagnosis mNGS provided.

Learn more about metagenomics

Featured

NEJM-min

THE NEW ENGLAND JOURNAL OF MEDICINE 2019

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

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References and Citations
  1. Benoit, P., et al. Nature Medicine, in press.
  2. Wilson MR, Sample HA, Zorn KC, et al. Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis.N Engl J Med 2019; 380:2327–40.
  3. Wilson MR, et al. Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing. N Engl J Med 2014;370:2408-2417