Research

Evidence Spotlight

Largest study on mNGS using CSF confirms its impact in diagnosing serious neurological infections

A groundbreaking study published in Nature Medicine, the largest of its kind, establishes mNGS as a crucial diagnostic tool for central nervous system (CNS) infections. Findings showed that mNGS technology significantly enhances diagnostic yield, supporting faster, targeted treatment decisions for patients.

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webinar

mNGS for Recurrent HSV Encephalitis with Atypical Presentation in a Child

Molly Wilson-Murphy, M.D., Boston Children’s Hospital
webinar

Diagnosis of Meningitis and Encephalitis in Pediatric Patients Using Metagenomic Next-Generation Sequencing (mNGS)

Sudeb Dalai, M.D., Ph.D., Delve Bio, Vice President, Medical Affairs
webinar

Metagenomic Next-Generation Sequencing: Updates on A Cutting-Edge Diagnostic Tool

Chaz Langelier, MD, PhD, Associate Professor of Medicine, Division of Infectious Diseases and Assistant Medical Director, Hospital Epidemiology and Infection Prevention, UCSF Health & Natasha Spottiswoode, MD, PhD, Assistant Professor, UCSF Health Division of Infectious Diseases
webinar

The Case for Early Adoption of mNGS Pathogen Detection

Kyle Rodino, Ph.D., D(ABMM), Perelman School of Medicine, University of Pennsylvania
webinar

Delve Detect: Metagenomic Next Generation Sequencing for Broad, Agnostic Pathogens in CSF

Charles Chiu, M.D., Ph.D., Professor, Laboratory Medicine and Medicine / Infectious Diseases, University of California San Francisco (UCSF), Co-Director, UCSF Clinical Microbiology Laboratory.
webinar

Diagnosing CNS Infections: The Potential of Metagenomics

Kiran T. Thakur, M.D., Columbia University Medical Center, Herbert Irving Associate Professor of Neurology, Director, Program in Neuroinfectious Diseases, Department of Neurology. Steve Miller, M.D., Ph.D., Delve Bio, Chief Medical Officer.
webinar

Metagenomic Sequencing: Broad, Agnostic Detection of Pathogens

Melissa B. Miller, PhD, D(ABMM), FAAM, FIDSA, James D. Fold Distinguished Professor, Pathology and Laboratory Medicine, Director, Clinical Microbiology and Molecular Microbiology Laboratories, University of North Carolina at Chapel Hill. Anna Piantadosi, MD, PhD, Assistant Professor, Pathology and Laboratory medicine, Infectious Diseases, Emory University School of Medicine.
podcast

The Encephalitis Podcast: Metagenomics & Encephalitis with Professor Michael Wilson

Dr. Ava Easton was joined by Professor Michael Wilson from the Centre of Encephalitis and Meningitis at UCSF to talk about metagenomics and encephalitis.
webinar

Clinical Metagenomic Next Generation Sequencing for Diagnosis of Central Nervous System Infections

Charles Chiu, M.D., Ph.D., Professor, Laboratory Medicine and Medicine / Infectious Diseases, University of California San Francisco (UCSF), Co-Director, UCSF Clinical Microbiology Laboratory.

webinar 49:09

mNGS for Recurrent HSV Encephalitis with Atypical Presentation in a Child
webinar 11:23

Diagnosis of Meningitis and Encephalitis in Pediatric Patients Using Metagenomic Next-Generation Sequencing (mNGS)
webinar 58:07

Metagenomic Next-Generation Sequencing: Updates on A Cutting-Edge Diagnostic Tool
webinar 54:12

The Case for Early Adoption of mNGS Pathogen Detection
webinar 45:30

Delve Detect: Metagenomic Next Generation Sequencing for Broad, Agnostic Pathogens in CSF
webinar 51:02

Diagnosing CNS Infections: The Potential of Metagenomics
webinar 39:35

Metagenomic Sequencing: Broad, Agnostic Detection of Pathogens
podcast 32:49

The Encephalitis Podcast: Metagenomics & Encephalitis with Professor Michael Wilson
webinar 37:16

Clinical Metagenomic Next Generation Sequencing for Diagnosis of Central Nervous System Infections

Ebook

How metagenomic next generation sequencing is revolutionizing how we treat and manage infectious diseases

Metagenomic next-generation sequencing is rewriting what’s possible in pathogen detection, microbiome research, and beyond. This 5-chapter guide cuts through the noise: from sequencing fundamentals to real-world implementation, wet lab considerations to bioinformatics pipelines, and the strategic decisions that separate teams who get results from teams who get data.
Chapter 1 is yours immediately, free and ready to view.

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Chapters 2–5 are available in full.  Tell us a bit about yourself and we’ll send you the complete guide.

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Case studies

Delve Detect CSF

CSF mNGS Guided Experimental Antiviral Therapy and Detection of Disease Recurrence in Cache Valley Virus Meningoencephalitis

Read about Delve Detect CSF Read More

Delve Detect CSF
HSV-1 in CSF

Atypical Pediatric HSV-1 Encephalitis Following Initially Negative CSF Testing and Antiviral Re-initiation

Read about HSV-1 in CSF Read More

HSV-1 in CSF
Aspergillus terreus and VZV in CSF

Rapid Identification of Dual CNS Infection with Aspergillus terreus and VZV in an Immunocompromised Host Leading to Antiviral Initiation and Clarification of Antifungal Therapy

Read about Aspergillus terreus and VZV in CSF Read More

Aspergillus terreus and VZV in CSF
Taenia solium in CSF

Rapid Diagnosis of Subarachnoid Neurocysticercosis
Preventing ICP Crisis and Enabling Full Neurologic Recovery

Read about Taenia solium in CSF Read More

Taenia solium in CSF
Streptococcus intermedius in CSF

Culture-Negative CNS Abscess with CSF Detection of Streptococcus intermedius After Nondiagnostic Aspiration, Avoiding Additional Invasive Sampling

Read about Streptococcus intermedius in CSF Read More

Streptococcus intermedius in CSF

Featured

OPEN FORUM INFECTIOUS DISEASES 2025

Evaluating the Clinical Impact of Metagenomic Next-Generation Sequencing in CNS Infections: A Diagnostic Pathway and Resource Utilization Modeling Study

Read Now

Most Recent

OPEN FORUM INFECTIOUS DISEASES 2025

Metagenomic Next-generation Sequencing in Patients With Infectious Meningoencephalitis: A Comprehensive Systematic Literature Review and Meta-analysis
NATURE MEDICINE 2024

Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections
THE LANCET 2023

Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation
NEUROLOGY NEUROIMMUNOLOGY & NEUROINFLAMMATION 2023

Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis
NATURE COMMUNICATIONS 2022

Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.
NAT MED 2021

Rapid Pathogen Detection by Metagenomic Next-Generation Sequencing of Infected Body Fluids.
AMERICAN SOCIETY FOR MICROBIOLOGY 2021

Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY 2021

Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review
NATURE REVIEWS: NEUROLOGY 2020

Metagenomics for neurological infections — expanding our imagination.
THE NEW ENGLAND JOURNAL OF MEDICINE 2019

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.
OPEN FORUM INFECTIOUS DISEASES 2019

The Comparative Utility Of Metagenomic Next-Generation Sequencing and Universal PCR for Pathogen Detection on Cerebrospinal Fluid: A Retrospective Analysis From a Tertiary Care Center
NATURE REVIEWS: GENETICS 2019

Clinical metagenomics.
THE NEW ENGLAND JOURNAL OF MEDICINE 2014

Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing.

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Research

Backed by Clinical Evidence

Real world evidence from more than 4800 samples over 7 years found Delve Detect delivers 22% greater diagnostic yield than all other infectious disease tests combined.

Evidence Spotlight

Largest study on mNGS using CSF confirms its impact in diagnosing serious neurological infections

Webinars and Podcasts

mNGS for Recurrent HSV Encephalitis with Atypical Presentation in a Child

Diagnosis of Meningitis and Encephalitis in Pediatric Patients Using Metagenomic Next-Generation Sequencing (mNGS)

Metagenomic Next-Generation Sequencing: Updates on A Cutting-Edge Diagnostic Tool

The Case for Early Adoption of mNGS Pathogen Detection

Delve Detect: Metagenomic Next Generation Sequencing for Broad, Agnostic Pathogens in CSF

Diagnosing CNS Infections: The Potential of Metagenomics

Metagenomic Sequencing: Broad, Agnostic Detection of Pathogens

The Encephalitis Podcast: Metagenomics & Encephalitis with Professor Michael Wilson

Clinical Metagenomic Next Generation Sequencing for Diagnosis of Central Nervous System Infections

mNGS for Recurrent HSV Encephalitis with Atypical Presentation in a Child

Diagnosis of Meningitis and Encephalitis in Pediatric Patients Using Metagenomic Next-Generation Sequencing (mNGS)

Metagenomic Next-Generation Sequencing: Updates on A Cutting-Edge Diagnostic Tool

The Case for Early Adoption of mNGS Pathogen Detection

Delve Detect: Metagenomic Next Generation Sequencing for Broad, Agnostic Pathogens in CSF

Diagnosing CNS Infections: The Potential of Metagenomics

Metagenomic Sequencing: Broad, Agnostic Detection of Pathogens

The Encephalitis Podcast: Metagenomics & Encephalitis with Professor Michael Wilson

Clinical Metagenomic Next Generation Sequencing for Diagnosis of Central Nervous System Infections

How metagenomic next generation sequencing is revolutionizing how we treat and manage infectious diseases

Case studies

Delve Detect CSF

CSF mNGS Guided Experimental Antiviral Therapy and Detection of Disease Recurrence in Cache Valley Virus Meningoencephalitis

Delve Detect CSF

HSV-1 in CSF

Atypical Pediatric HSV-1 Encephalitis Following Initially Negative CSF Testing and Antiviral Re-initiation

HSV-1 in CSF

Aspergillus terreus and VZV in CSF

Rapid Identification of Dual CNS Infection with Aspergillus terreus and VZV in an Immunocompromised Host Leading to Antiviral Initiation and Clarification of Antifungal Therapy

Aspergillus terreus and VZV in CSF

Taenia solium in CSF

Rapid Diagnosis of Subarachnoid Neurocysticercosis Preventing ICP Crisis and Enabling Full Neurologic Recovery

Taenia solium in CSF

Streptococcus intermedius in CSF

Culture-Negative CNS Abscess with CSF Detection of Streptococcus intermedius After Nondiagnostic Aspiration, Avoiding Additional Invasive Sampling

Streptococcus intermedius in CSF

Publications

Evaluating the Clinical Impact of Metagenomic Next-Generation Sequencing in CNS Infections: A Diagnostic Pathway and Resource Utilization Modeling Study

Metagenomic Next-generation Sequencing in Patients With Infectious Meningoencephalitis: A Comprehensive Systematic Literature Review and Meta-analysis

Seven-year performance of a clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections

Transmission of yellow fever vaccine virus through blood transfusion and organ transplantation in the USA in 2021: report of an investigation

Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis

Integrating central nervous system metagenomics and host response for diagnosis of tuberculosis meningitis and its mimics.

Rapid Pathogen Detection by Metagenomic Next-Generation Sequencing of Infected Body Fluids.

Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis.

Metagenomic Next-Generation Sequencing for Diagnosis of Pediatric Meningitis and Encephalitis: A Review

Metagenomics for neurological infections — expanding our imagination.

Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.

The Comparative Utility Of Metagenomic Next-Generation Sequencing and Universal PCR for Pathogen Detection on Cerebrospinal Fluid: A Retrospective Analysis From a Tertiary Care Center

Clinical metagenomics.

Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing.

Want to hear more about our technology?

Rapid Diagnosis of Subarachnoid Neurocysticercosis
Preventing ICP Crisis and Enabling Full Neurologic Recovery